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New evidence is increasingly suggesting that isotretinoin may be best prescribed using a lower daily dose, with the regimen tailored to the individual patient, the severity of their acne and their response to the medicine. There are several problems with prescribing isotretinoin based on a high daily dose to reach a cumulative total amount, including: 3. It is likely that the higher dose group represents traditional weight-based prescribing. The current total average daily dose of isotretinoin is 42 mg. Adverse effects of isotretinoin are dose dependent and become more common, and more severe, with higher doses.

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This medicinal product is subject to additional monitoring. Isotretinoin should only be prescribed by or under the supervision of physicians with expertise in the use of systemic retinoids for the treatment of severe acne and a full understanding of the risks of isotretinoin therapy and monitoring requirements.
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- Blood lipids should be checked after first month, no more tests needed unless important change is noted.
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- A total of 91 drugs are known to interact with isotretinoin.
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Low-dose isotretinoin has been used successfully in mild to moderate papulopustular acne. To test whether the roxithromycin accutane 20mg of an antibacterial enables use of isotretinoin in low doses even in moderate to severe acne. This was a preliminary open-label, prospective, non-comparative, single-centre study carried out in a tertiary-care referral hospital. A combination of low-dose isotretinoin and oral azithromycin pulse is effective in severe acne and has a reasonably acceptable adverse-effect profile and low post-treatment relapse rates. Frequently asked questions.

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