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In patients who have severe intolerance to the recommended dose, treatment may be continued at a lower dose for a longer duration. Doses may be adjusted according to patient response and tolerance. In case of relapse, may consider a 2nd course of treatment using the same daily dose and cumulative treatment dose; allow at least a 2-month drug-free period between treatments. Adult: For the treatment of mild to moderate cases with or without inflammation: As 0. Effect may be observed after weeks of treatment.
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Isotretinoin must not be taken by patients who are pregnant or who may become pregnant. There is a high risk that isotretinoin will cause loss of the pregnancy, or will cause the baby to be born too early, to die shortly after birth, or to be born with birth defects physical problems that are present at birth. Do not buy isotretinoin over the internet. You will need to see your doctor every month during your treatment to talk about your condition and the side effects you are experiencing. Your pharmacist cannot dispense your medication if you come to pick it up after the allowed time period has passed. Your doctor will give you an identification number and card when you start your treatment.

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Apart from the consultant pain physician, who else should be informed of the CMP and prescription.
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