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Since vitamin D normally enhances calcium absorption from the intestines and its release from bone, hypercalcaemia is a potential side effect. However, only rarely is sufficient amounts of drug absorbed to affect calcium homeostasis in this way.
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The result is increased protein synthesis that mediates the cellular response. Some ion channels are linked directly to a receptor, others are activated by G-proteins and drugs that interact with these receptors will affect the functioning of the channels. However, drugs can also affect channel function by binding directly to parts of the channel protein. Some drugs physically block channels.
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The most important conjugation reaction is with glucuronic acid to form a glucuronide. Other conjugations occur with sulfate, acetyl, methyl and glycine groups. Many drugs are metabolized by a combination of routes and this can vary from individual to individual and depends on the dose of drug, the presence of interacting drugs and the state of the liver. Metabolism of aspirin and paracetamol.
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