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Because the outcomes are rare and the duration of medication use was brief, few events occurred. The prevalence is even greater among older adults and has been increasing during the past 15 years 1. In recent years, several medications have received US Food and Drug Administration FDA approval as adjuncts to diet and lifestyle modifications for the management of obesity. It acts as an appetite suppressant via the central nervous system. Topiramate TPM is an anticonvulsant indicated for use in the treatment of migraine and epilepsy. One of the known effects of TPM is a decrease in appetite. Consequently, it is sometimes prescribed off-label for weight loss 3. Typical dosing of PHEN is 15 to Therefore, a randomized, prospective postmarketing outcome study of major adverse CV events MACE was requested by a regulatory agency. The present retrospective cohort study was conducted in the Truven Health MarketScan Databases Commercial and Medicare Supplemental administrative claims.

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UK, remember your settings and improve government services. This list is not exhaustive. Falls within Schedule 5 if any preparation of one or more of the substances to which this note applies, not being a preparation designed for administration by injection, when compounded with one or more other active or inert ingredients and containing a total of not more than milligrams of the substance or substances calculated as base per dosage unit or with a total concentration of not more than 2. Falls within Schedule 5 if in a preparation designed for oral administration, containing not more than mg of dextropropoxyphene calculated as base per dosage unit or with a concentration of not more than 2. Falls within Schedule 5 if in any preparation of difenoxin containing, per dosage unit, not more than 0. Falls within Schedule 5 if in any preparation of diphenoxylate containing, per dosage unit, not more than 2.

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