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Phenylpropanolamine PPA is a sympathomimetic agent which is used as a decongestant and appetite suppressant. In veterinary medicine, it is used to control urinary incontinence in dogs. There are four optical isomers of PPA: dextro- and levo-norephedrine, and dextro- and levo-norpseudoephedrine. Exogenous compounds in this family are degraded too rapidly by monoamine oxidase to be active at all but the highest doses. In Canada, it was withdrawn from the market on 31 May PPA acts primarily as a selective norepinephrine releasing agent. Many sympathetic hormones and neurotransmitters are based on the phenethylamine skeleton, and function generally in fight or flight type responses, such as increasing heart rate, blood pressure, dilating the pupils, increased energy, drying of mucous membranes, increased sweating, and a significant number of additional effects. Because of the dopaminergic action of the drugs and previous findings from electrode stimulation of the brain e. PPA is also still available in Germany.

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