Ambien CR is the brand name for the sedative zolpidem, a non-barbiturate hypnotic medication. It is a central nervous depressant, and is used in the treatment of insomnia. Although each case differs, Ambien CR is usually prescribed for short-term use one or two days, but not for longer than two weeks. The outer coating of the medication dissolves quickly to induce sleepiness; the remainder of the medication is released slowly through the night to help sustain sleep. Do not chew, split, or crush the tablet. Although this medication is taken on an as needed basis, at least seven or eight hours of uninterrupted sleep time must be available before taking Ambien CR; plan to go to bed immediately after taking this medication.

Zolpidem is used to treat insomnia difficulty falling asleep or staying asleep. Ambien Cr Zolpidem Tartrate Er.

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Each tablet contains zolpidem tartrate 6. Excipient with known effect: Lactose monohydrate. Zolpidem selectively binds the omega-1 receptor subtype also known as the benzodiazepine-1 subtype which is the alpha unit of the GABA-A receptor complex. Whereas benzodiazepines non-selectively bind all three omega receptor subtypes, zolpidem preferentially binds the omega-1 subtype. The modulation of the chloride anion channel via this receptor leads to the specific sedative effects demonstrated by zolpidem i. These effects are reversed by the benzodiazepine antagonist flumazenil. In humans: The preservation of deep sleep stages 3 and 4 - slow-wave sleep may be explained by the selective omega-1 binding by zolpidem. All identified effects of zolpidem are reversed by the benzodiazepine antagonist flumazenil. In addition, no evidence of next-day residual effects were detected with zolpidem STILNOX CR exhibits biphasic absorption characteristics, which result in rapid initial absorption and provide extended plasma concentrations beyond 3 hours after administration.

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