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Common side effects include daytime sleepiness, headache, nausea, and diarrhea. Zolpidem is a nonbenzodiazepine Z drug which acts as a sedative and hypnotic. Zolpidem is labelled for short-term usually about two to six weeks treatment of insomnia at the lowest possible dose. It can be taken if there are at least 4 hours between the time of administration and when the person must be awake. Alcohol has cross tolerance with GABA A receptor positive allosteric modulators, such as the benzodiazepines and the nonbenzodiazepine drugs.

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Ambien is branded name of zolpidem tartrate tablets manufactured by an American company Sanofi-Aventis. The active ingredient in both is still zolpidem tartrate, so we will be focusing on Ambien in this article. It is manufactured in 5 mg and 10 mg strength tablets to be taken orally through the mouth. The main FDA-approved indication for Ambien is short-term insomnia treatment, in cases when the patient has trouble initiating sleep. Additionally, zolpidem was researched as a potential treatment for other neurologic disorders. Just like with benzodiazepines, its sedative and hypnotic effects are caused by subunit modulation of the chloride channel of the GABA receptor.

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