Common side effects include headache, muscle pain, flushed skin, and nausea. Tadalafil was approved for medical use in the United States in Tadalafil is used to treat erectile dysfunction ED, benign prostatic hyperplasia BPH, and pulmonary arterial hypertension. The price of the 5 mg and 2. Tadalafil 40 mg is approved in the United States, Canada, and Japan as a once-daily therapy to improve exercise ability in patients with pulmonary arterial hypertension PAH. The pulmonary vascular lumen is decreased in PAH as a result of vasoconstriction and vascular remodeling, resulting in increased pulmonary artery pressure and pulmonary vascular resistance. Tadalafil causes pulmonary artery vasodilation, and inhibits vascular remodeling, thus lowering pulmonary arterial pressure and resistance.

Objective: To assess the long-term safety and tolerability of tadalafil for patients with erectile dysfunction ED. Patients and methods: This was a multicentre, open-label, month extension trial involving men with ED. The mean age was 57 range years and These patients had participated in 1 of 5 previous 8-week or week randomised, double-blind, placebo-controlled tadalafil studies. Results: Four hundred ninety-three The total tadalafil exposure was

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