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Common side effects include headache, muscle pain, flushed skin, and nausea. Tadalafil is used to treat erectile dysfunction ED, benign prostatic hyperplasia BPH, and pulmonary arterial hypertension. The pulmonary vascular lumen is decreased in PAH as a result of vasoconstriction and vascular remodeling, resulting in increased pulmonary artery pressure and pulmonary vascular resistance. Tadalafil causes pulmonary artery vasodilation, and inhibits vascular remodeling, thus lowering pulmonary arterial pressure and resistance. Right heart failure is the principal consequence of severe pulmonary arterial hypertension. The most common potential side effects when using tadalafil are headache, stomach discomfort or pain, indigestion, burping, acid reflux, back pain, muscle aches, flushing, and stuffy and runny nose. These side effects reflect the ability of PDE5 inhibition to cause vasodilation cause blood vessels to widen, and usually resolve after a few hours.

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Tadalafil, sold under the brand name Cialis among others, is a medication used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. Common side effects include headache, muscle pain, flushed skin, and nausea. Tadalafil was approved for medical use in the United States in Tadalafil is used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. Tadalafil was found to have similar benefits for lower urinary tract symptoms as the usually prescribed tamsulosin. Tadalafil is approved in the United States, Canada, and Japan to improve exercise ability in people with pulmonary arterial hypertension.

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