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Please note that this medicine may be available in various strengths for each active ingredient listed above. This is not a comprehensive list. These side effects are possible but do not always occur. Some of the side effects may be rare but serious. Some health conditions may make you more susceptible to the side effects of the drug. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. The precise mechanism by which the rpoB mutations alter the expression pattern of RNA polymerase is not entirely clear.

The mutations cluster in two distinct locations within RNA polymerase and are most likely to alter the function of RNA polymerase in distinct ways. We note that a fluoroquinolone-resistant clinical isolate of E. Thus, some rifampicin resistance mutations increase the resistance of E. We searched the publicly available WGS data of ciprofloxacin-resistant clinical isolates of E.

Fluoroquinolones are now being increasingly used as second-line drugs for treating MDR Mycobacterium tuberculosis. Medicinal potential of ciprofloxacin and its derivatives. Future Med Chem ; 5: 81 — Containment of antimicrobial resistance due to use of antimicrobial agents in animals intended for food: WHO perspective. Rev Sci Tech ; — Fluoroquinolones, antimicrobial resistance and neutropenic cancer patients. Curr Opin Infect Dis ; — The role of fluoroquinolones in the management of urinary tract infections in areas with high rates of fluoroquinolone-resistant uropathogens.

Fluoroquinolones: action and resistance. Curr Top Med Chem ; 3: — Interplay in the selection of fluoroquinolone resistance and bacterial fitness. PLoS Pathog ; 5: e Can phylogenetic type predict resistance development? J Antimicrob Chemother ; — Constitutive SoxS expression in a fluoroquinolone-resistant strain with a truncated SoxR protein and identification of a new member of the marA-soxS-rob regulon, mdtG.

Antimicrob Agents Chemother ; — The complete genome sequence of Escherichia coli K Science ; — High efficiency mutagenesis, repair, and engineering of chromosomal DNA using single-stranded oligonucleotides. Mol Microbiol ; — Selection of resistant bacteria at very low antibiotic concentrations. PLoS Pathog ; 7: e Compensatory evolution in rifampin-resistant Escherichia coli. Genetics ; — Fitness-compensatory mutations in rifampicin-resistant RNA polymerase.

Genetic characterization of compensatory evolution in strains carrying rpoB SerLeu, the rifampicin resistance mutation most frequently found in clinical isolates. J Antimicrob Chemother ; — 7. Comprehensive phenotypic characterization of rifampicin resistance mutations in Salmonella provides insight into the evolution of resistance in Mycobacterium tuberculosis. J Antimicrob Chemother ; — 5. J Bacteriol ; — J Mol Biol ; 72 — Nucleic Acids Res ; — Quinolone resistance due to reduced target enzyme expression.

Functional characterisation of altered outer membrane proteins for tetracycline resistance in Escherichia coli. Int J Antimicrob Agents ; — 9. Apirion D, Schlessinger D. Coresistance to neomycin and kanamycin by mutations in an Escherichia coli locus that affects ribosomes.

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