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Are six cycles of ovulation induction with gonadotrophins more cost-effective than six cycles of ovulation induction with clomiphene citrate CC with or without IUI in normogonadotropic anovulatory women not pregnant after six ovulatory cycles with CC? In women with normogonadotropic anovulation who ovulate but do not conceive after six cycles with CC, medication is usually switched to gonadotrophins, with or without IUI. Between December and December women were allocated to six cycles with gonadotrophins plus IUI, six cycles with gonadotrophins plus intercourse, six cycles with CC plus IUI or six cycles with CC plus intercourse. The primary outcome was conception leading to a live birth achieved within 8 months of randomization. We calculated the direct medical costs of ovulation induction with gonadotrophins versus CC and of IUI versus intercourse in six clomiphene 50mg how much does it cost cycles. We included costs of medication, cycle monitoring, interventions, and pregnancy leading to live birth. We used non-parametric bootstrap resampling to investigate the effect of uncertainty in our estimates. We allowed participating hospitals to use their local protocols for ovulation induction and IUI, which may have led to variation in costs, but which increases generalizability.
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