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Prostanoids are a group of lipid hormone mediators that are derived from C fatty acids by the action of cyclooxygenases 1 and 2. They consist of the prostaglandins PG and the thromboxanes Tx and elicit a wide variety of biological responses through activation of G-protein-coupled receptors. The prostanoid receptor family consists of eight distinct rhodopsin-like receptor proteins, each being the product of an individual gene Coleman et al. With the recent identification of prostaglandin D 2 as a potent agonist at the CRTH 2 chemottractant receptor homologous molecule of TH2 cells receptor Hirai et al. The prostanoid receptors may be grouped according to the G-proteins to which they preferentially couple. Regulation of venous and arterial smooth muscle tone is a major role for prostanoid receptors across all mammalian species. In almost all vascular preparations studied, a mixed population of relaxatory prostanoid receptors has been observed. Piglet saphenous vein PSV contains prostanoid receptors coupled to smooth muscle relaxation.

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