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The history and development of non-medical prescribing is explained together with consideration of the different forms this can take, for example supplementary and independent prescribing. The current situation regarding access, supply and prescription of medicines by physiotherapists, radiographers and podiatrists is discussed. There are a number of pieces of legislation concerned with the sale, supply and use of drugs. The major ones are the Medicines Act plus associated Schedules, Orders, Regulations and European Directives. These Acts of Parliament deal with substances that are known as medicinal products within the meaning of the Act(s).

Presently, ring-fenced monies from the Department of Health are managed by Strategic Health Authorities to fund these courses in an attempt to promote non-medical prescribing. There will come a point, however, when this funding is withdrawn. All Trust and university-based training offered to radiographers in this area is normally on a multi-professional basis. There is very little published evidence to indicate how and when PGDs and supplementary prescribing can be used in radiography (Hogg and Hogg, Hogg and Hogg practices have had on radiography patient care and management.

Skin reactions can be treated with oral or intravenous antihistamines, which also have an antiemetic effect. Intravenous corticosteroids may be required for serious urticaria. A number of drugs are used as adjuncts to radiography. They can be administered by qualified, registered and trained radiographers under patient group directions. Analgesia may be necessary for the after-effects of venepuncture or following therapeutic radiographic procedures.

Formation of a false nucleotide inhibits an enzyme necessary for DNA synthesis. This is similar to the mode of action of the antifungal drug, flucytosine. Fluorouracil is used to treat gastrointestinal and breast cancers, often together with synthetic folinates. Adverse effects of fluorouracil are less likely, but similar to methotrexate. Cytarabine is a pyrimidine analogue, which is incorporated into both RNA and DNA and interferes with the action of DNA polymerase.

The antigen reacts with IgE attached to the mast cells in the lung causing the release of pharmacologically active mediators. These mediators include histamine and prostaglandins together with a range of other substances in small quantities (for example leukotrienes). The immediate effects are due principally to the action of histamine and include hyper-responsiveness and constriction of bronchial smooth muscle and inflammation of bronchial epithelium. Both of these effects combine to produce an increase in airway resistance, that is, a narrowing of the airway and difficulty breathing out. Other symptoms are wheezing and coughing.

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