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Hydroxyzine is used in adults and children to relieve itching caused by allergic skin reactions. It is also used alone or with other medications in adults and children to relieve anxiety and tension. Hydroxyzine is also used along with other medications in adults and children as a sedative before and after general anesthesia for surgery. It works by blocking the action of histamine a substance in the body that causes allergic symptoms. It also works by decreasing activity in the brain. Hydroxyzine comes as capsules, tablets, a syrup, and suspension to take by mouth. It usually is taken three or four times a day. Take hydroxyzine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. This medication may be prescribed for other uses.

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Everyone has two copies of each of these genes—one copy inherited from each parent. People who inherit harmful variants in one of these genes have increased risks of several cancers—most notably breast and ovarian cancer, but also several additional types of cancer. The risk for any one woman depends on a number of factors, some of which have not been fully characterized. In women, these include fallopian tube cancer 5, 6 and primary peritoneal cancer 7, both of which start in the same cells as the most common type of ovarian cancer. In addition, certain variants in BRCA1 and BRCA2 can cause subtypes of Fanconi anemia, a rare syndrome that is associated with childhood solid tumors and development of acute myeloid leukemia 15 — The mutations that cause these Fanconi anemia subtypes have a milder effect on protein function than the mutations that cause breast and ovarian cancer.

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