Levothyroxine a thyroid hormone should not be used alone or along with other treatments to treat obesity or cause weight loss. Levothyroxine may cause serious or life-threatening problems when given in large doses, especially when taken with amphetamines such as amphetamine Adzenys, Dyanavel XR, Evekeo, dextroamphetamine Dexedrine, and methamphetamine Desoxyn. Levothyroxine is used to treat hypothyroidism condition where the thyroid gland does not produce enough thyroid hormone. It is also used with surgery and radioactive iodine therapy to treat thyroid cancer. It works by replacing thyroid hormone that is normally produced by the body. When taken correctly, levothyroxine reverses these symptoms.

All FDA black box warnings are at the end of this fact sheet. Bupropion is an antidepressant medication that works in the brain. It is approved for the treatment of major depressive disorder MDD, seasonal affective disorder SAD, and to help people quit smoking smoking cessation. SAD is a type of depression that occurs mainly during the autumn-winter season. They should be clear about the limits of the research around that medication and if there are any other options. After starting bupropion, symptoms gradually decrease over a period of weeks. In MDD and SAD, sleep and other physical symptoms may improve before there is noticeable improvement in mood or interest in activities.

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