The first endocrine therapy was surgical oophorectomy in young women with advanced disease 8. Stilboestrol became the mainstay of oestrogen therapy until the development of tamoxifen 30 years later. The lead compound for tamoxifen development was found to be a mixture of cis and trans isomers. The first single-arm Phase 2 trial of tamoxifen was initiated in Thus, tamoxifen retained its place as the lead SERM and there still remains interest in developing analogues of tamoxifen with greater activity and reduced toxicity 18.

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Tamoxifen may cause cancer of the uterus womb, strokes, and blood clots in the lungs. These conditions may be serious or fatal. Tell your nolvadex 40mg price in india if you have ever had a blood clot in the lungs or legs, a stroke, or a heart attack. Also tell your doctor if you smoke, if you have high blood pressure or diabetes, if your ability to move around during your waking hours is limited, or if you are taking anticoagulants 'blood thinners' such as warfarin Coumadin. Keep all appointments with your doctor.

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Oral Reduction of breast cancer incidence in women at high risk Adult: 20 mg daily for 5 years. Adult: Usual dose: 20 mg daily, given as a single dose or in 2 divided doses. Doses of up to 40 mg daily may be given in advanced or metastatic cases; however, no additional clinical benefit has been demonstrated. Adult: In women with regular menstruation, but with anovular cycles: Initially, 20 mg daily given on days of the menstrual cycle. If initial treatment course is unsuccessful, doses may be increased during subsequent menstrual periods to 40 mg then to 80 mg daily. In women with irregular menstruation: Initial course may begin on any day; if there is no response, a subsequent treatment course may start 45 days later with the dose increased to 40 mg then to 80 mg daily.

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Nandrolone phenylpropionate NPP, or nandrolone phenpropionate, sold under the brand name Durabolin among others, is an androgen and anabolic steroid AAS medication which has been used primarily in the treatment of breast cancer and osteoporosis in women. Side effects of NPP include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire. NPP was first described in and was introduced for medical use in NPP nolvadex 20mg tablets been used mainly in the treatment of advanced breast cancer in women and as an adjunct therapy for the treatment of senile or postmenopausal osteoporosis in women. Antiestrogens like aromatase inhibitors e.

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