Everyone has two copies of each of these genes—one copy inherited from each parent. People who inherit harmful variants in one of these genes have increased risks of several cancers—most notably breast and ovarian cancer, but also several additional types of cancer. The risk for any one woman depends on a number of factors, some of which have not been fully characterized. In women, these include fallopian tube cancer 5, 6 and primary peritoneal cancer 7, both of which start in the same cells as the most common type of ovarian cancer. In addition, certain variants in BRCA1 and BRCA2 can cause subtypes of Fanconi anemia, a rare syndrome that is associated with childhood solid tumors and development of acute myeloid leukemia 15 — The mutations that cause these Fanconi anemia subtypes have a milder effect on protein function than the mutations that cause breast and ovarian cancer. Children who inherit one of these variants from each parent will develop Fanconi anemia.

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