Researchers are well aware of the phenomenon. What Is the Role of Hormones in MS Symptoms While the cause of premenstrual symptom exacerbation is unknown, hormones are thought to play a role. Weigel suggests that the decrease in estrogen levels leading up to menstruation may contribute to the worsening of MS symptoms. But all 7 of the 23 participants who were taking oral contraceptives experienced generally milder symptoms while taking the pills and a return to baseline symptom severity during the pill-free interval. Weigel says hormone-based contraception is a personal decision, and its safety depends on your age, smoking status, mobility status, and other aspects of your medical history. However, for some women, hormone-based contraceptive can make a difference in severity of PMS symptoms. But Repovic notes that this does not include some of the more unusual therapies, such as cyclophosphamide Cytoxan or mitoxantrone Novantrone.

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