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The approved indications are specified as in combination with diet for the treatment of in adults; in combination with diet for treatment of patients with primary. Interestingly for the dyslipidemia-drug playing field, Merck's patent on the nonstatin cholesterol-lowering agent ezetimibe Zetia is also due to expire this year. But as a class, statins have been among the most widely prescribed drugs in history. Those agents have as yet demonstrated their mettle in large randomized trials primarily for the surrogate end point of LDL-C reduction. Large mortality trials for those agents are ongoing and may have a lot to say about whether the PCSK9 inhibitors become more widely used. Specialty: Multispecialty.

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