Within 1 to 2 weeks for control of aggression, agitation, insomnia; 3 to 6 weeks for control of mania and positive psychotic symptoms. Maximum plasma concentrations after IM administration are 5 times higher than maximum plasma concentrations produced by an oral dose. Bipolar disorder oral: Treatment of acute manic or mixed episodes of bipolar I disorder as monotherapy or in combination with lithium or valproate and maintenance treatment; treatment of bipolar depression in combination with fluoxetine. Major depressive disorder unipolar, treatment resistant oral: Treatment of treatment-resistant depression in combination with fluoxetine. Data from a limited number of patients suggest that olanzapine may be beneficial in the treatment of hypomania. Data from a randomized, phase 2 study that included chemotherapy-naive patients who received moderately and highly emetogenic chemotherapy regimens also suggest that oral olanzapine in combination with dexamethasone and palonosetron may be beneficial for prevention of acute and delayed nausea and vomiting.

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