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Donepezil is both excreted in the urine intact and extensively metabolized to four major metabolites, two of which are known to be active, and a number of minor metabolites, not all of which have been identified. Three of the aricept purchase canada metabolites of donepezil have not undergone extensive safety tests in animals. These comprise two O -demethylated derivatives and an N -oxidation product. The rate of metabolism of donepezil is slow and does not appear to be saturable. Pharmacokinetic studies also demonstrated that the metabolism of donepezil is not affected by concurrent administration of digoxin or cimetidine. Morning dosing of donepezil is recommended to minimize insomnia.
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Aricept improves the function of nerve cells in the brain. This medication works in the brain by improving thinking, memory, attention and the ability to do daily tasks. This medication is available in the strength of 5mg and 10mg and 23mg tablets. You should not take this medication if you are allergic to Donepezil or any ingredients of the medication. Before you start taking this medication, talk to your doctor about your medical history and about all the medications you are currently taking including OTC and herbal medications. This drug may make you dizzy or drowsy.
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