Preparations vary widely in bioavailability ; changing the preparation requires the same precautions as initiation of treatment. Long-term use of lithium has been associated with thyroid disorders and mild cognitive and memory impairment. Long-term treatment should therefore be undertaken only with careful assessment of risk and benefit, and with monitoring of thyroid function every 6 months more often if there is evidence of deterioration. The need for continued therapy should be assessed regularly and patients should be maintained on lithium after 3—5 years only if benefit persists. Abdominal discomfort; alopecia; angioedema; appetite decreased; arrhythmias; atrioventricular block; cardiomyopathy; cerebellar syndrome; circulatory collapse; coma; delirium; diarrhoea; dizziness; dry mouth; electrolyte imbalance; encephalopathy; folliculitis; gastritis; goitre; hyperglycaemia; hyperparathyroidism; hypersalivation; hypotension; hypothyroidism; idiopathic intracranial hypertension; leucocytosis; memory loss; movement disorders; muscle weakness; myasthenia gravis; nausea; neoplasms; nystagmus; peripheral neuropathy; peripheral oedema; polyuria; QT interval prolongation; reflexes abnormal; renal disorders; renal impairment; rhabdomyolysis; seizure; sexual dysfunction; skin reactions; skin ulcer; speech impairment; taste altered; thyrotoxicosis; tremor; vertigo; vision disorders; vomiting; weight increased. Signs of intoxication require withdrawal of treatment and include increasing gastro-intestinal disturbances vomiting, diarrhoea, visual disturbances, polyuria, muscle weakness, fine tremor increasing to coarse tremor, CNS disturbances confusion and drowsiness increasing to lack of coordination, restlessness, stupor ; abnormal reflexes, myoclonus, incontinence, hypernatraemia. For details on the management of poisoning, see Lithium, under Emergency treatment of poisoning.

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A year-old male patient was admitted to the hospital due to dysarthria, agitation, and confusion, which had started five days earlier. On clinical examination, the patient was agitated with sluggishness, coarse tremors, and myoclonus. Eleven years ago, he was admitted to the hospital with the same symptoms and toxic levels of lithium, so lithium intoxication was again suspected. Serum levels of lithium were determined and found elevated 2. Notably, the patient did not regularly measure his serum lithium levels.

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Lithium is used to treat manic episodes of bipolar disorder. Lithium takes about 1 to 3 weeks before it has an effect on these lithiums 600 mg. Lithium may also reduce the frequency of manic episodes if it is taken regularly. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

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Drug hypersensitivity syndrome DHS is one of the more severe cutaneous adverse drug reactions. It is characterized by a clinical triad of fever, skin rash and internal organ involvement. It has been given different names like dapsone syndrome, febrile mucocutaneous syndrome, drug rash with eosinophilia and systemic symptoms DRESS, and drug-induced delayed multi-organ hypersensitivity syndrome DIDMOHS. She has had depressive episodes in the past and a diagnosis of recurrent depressive disorder, currently severe depression with psychotic symptoms was made. Her serum lithium level was 1. The patient presented after approximately four weeks with symptoms of fever and generalized skin rash.

Lithium is a drug that doctors prescribe to people with bipolar disorder. It can help prevent and treat manic and depressive episodes. People with bipolar disorder may experience manic episodes, which involve a significantly elevated mood, and depressive episodes, which cause symptoms of depression. Lithium is often a long-term treatment for bipolar disorder. It can decrease the intensity of manic and depressive episodes, making symptoms less severe.

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Lithium salts have been commonly used for prophylaxis and treatment of bipolar disorder and have numerous side effects. Clonidine 0.1mg tablets examination revealed downbeat nystagmus and 6 prism diopters of right hypertropia. Other neurological examinations were also normal. We referred the patients to psychiatrist. Even within a normal therapeutic range, downbeat nystagmus and skew deviation can occur as side effect of lithium.

Lithium is an alkalai metal and mood stabilizer used in the treatment of all phases manic, maintenance, and depressive of bipolar I disorder. It is the gold standard treatment for bipolar I disorder and mania. Most risk factors for developing lithium toxicity involve changes in sodium levels or the way the patient's body handles sodium. Also, always remember to treat the patient and not the number! Serum lithium concentrations do not always reliably correlate with the clinical severity of toxicity. Last edited on July 13,

It is very important that you take the medicine at about the lithium 600 mg time every day. It will work best if you do this. Drink extra water while on this medicine. Adults should try to drink cups 48 to 64 oz. It is important that you keep taking each dose of this medicine on time even if you are feeling well.

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