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Pseudoephedrine PSE is a sympathomimetic drug of the phenethylamine and amphetamine chemical classes. Pseudoephedrine is a stimulant, but it is well known for shrinking swollen nasal mucous membranes, so it is often used as a decongestant. It reduces tissue hyperemia, edema, and nasal congestion commonly associated with colds or allergies. Other beneficial effects may include increasing the drainage of sinus secretions, and opening of obstructed Eustachian tubes. The same vasoconstriction action can also result in hypertension, which is a noted side effect of pseudoephedrine. Due to its stimulating qualities, however, the oral preparation is more likely to cause adverse effects, including urinary retention. Pseudoephedrine is indicated for the treatment of nasal congestion, sinus congestion, and Eustachian tube congestion. Pseudoephedrine is also used as a first-line prophylactic for recurrent priapism. Erection is largely a parasympathetic response, so the sympathetic action of pseudoephedrine may serve to relieve this condition.

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David Fischer, a clinical allergist in Barrie, Ont. Diphenhydramine is found in several brand-name and generic medicines for allergies or cold symptoms in North America, of which Benadryl is the best-known. The medicinal ingredient in Benadryl, diphenhydramine hydrochloride, makes you drowsy and irritable and if you take too high a dose or an overdose, you will end up in hospital, Fischer said. There is also the potential for fatal heart rhythm disturbances when combined with other medications. One of the biggest differences is that the newer medications cause much less, or no sedation.

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Cetirizine belongs to a class of medications known as histamine receptor antagonists. We carry most generic and brand name medication. Cetirizine is taken orally. You may experience dizziness, dry mouth, headache, loss of taste, drowsiness, or trouble sleeping. Talk to your healthcare practitioner if you need help managing side effects.

However, no antihistamine should be consumed with alcohol. Oral antihistamines can be used in addition to, but should not replace, epinephrine for the treatment of anaphylaxis. No other competing interests were declared. Chu, Paul Oykhman and Gordon L. Table 1: Summary of preferred antihistamines for allergy and urticaria.

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