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Asian Pacific Journal of Cancer Prevention, 14 8, Asian Pacific Journal of Cancer Prevention, 14, 8, Asian Pacific Journal of Cancer Prevention, ; 14 8: Chemoprotection refers to the use of specific natural or synthetic chemical agents to suppress or prevent theprogression to cancer. The purpose of this study is to assess the protective effect of aspirin, vitamin C or zinc ina dimethyl hydrazine DMH colon carcinoma model in rats and to investigate the effect of these supplementson changes associated with colonic zinc status. Groups 1, 2, 3 were simultaneously given aspirin, vitamin C, or zinc supplementrespectively from the beginning till the end of the study. The inhibitory effects are associated with maintaining the colonictissue zinc levels and zinc enzymes at near normal without significant changes.

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Without therapy, a gout flare usually resolves completely within a few days to several weeks, particularly in early disease. However, symptoms improve faster with treatment 1. Flares recur in the great majority of patients. With more frequent episodes, flares may be more severe and prolonged, and asymptomatic periods become shorter. The approach to asymptomatic hyperuricemia; the pathophysiology, clinical manifestations, and diagnosis of gout; and the prevention of recurrent gout after resolution of the gout flares are discussed separately However, these conditions would not preclude treatment with a nonsteroidal antiinflammatory drug NSAID or colchicine.

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