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Doses of 30 to mg are given at intervals throughout the day when maximum strength is needed for example, on rising and before mealtimes. The usual duration of action of a dose is 3 to cost of liv 52 hours in the daytime but a longer effect 6 hours is often obtained with a dose taken on retiring for bed. The total daily dose is usually in the range of 5 — 20 tablets but doses higher than these may be needed by some patients. Dosage should be increased gradually, in increments of 15 — 30mg daily, until maximum improvement is obtained. Total daily requirements are usually in the range to 30 — mg. Mestinon is mainly excreted unchanged by the kidney, therefore lower doses may be required in patients with renal disease and treatment should be based on titration of drug dosage to effect.
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MG is the most common disorder of neuromuscular transmission. See Chronic immunotherapy for myasthenia gravis and Role of thymectomy in patients with myasthenia gravis. The time of onset of clinical effect of each of these therapies for MG varies considerably table 1. This plays a large role, in addition to the pace and severity of the disease, in choosing the appropriate therapy for a given patient. Treatment goals and response assessment — The goals of therapy in MG are to render patients minimally symptomatic or better while minimizing side effects from medications. MG is a chronic but treatable disease, and many patients can achieve sustained remission of symptoms and full functional capacity.
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