The asterisk indicates patients who did not provide at least 1 postbaseline efficacy assessment. Mean least squares value change from baseline in monthly migraine frequency. Missing data were computed based on the frequency of migraines observed before discontinuation. Mean least squares value percentage change from baseline in body weight. Objective To assess the efficacy and safety of topiramate as a migraine-preventive therapy. Design A week, randomized, double-blind, placebo-controlled study. Patients Patients were aged 12 to 65 years, had a 6-month International Headache Society migraine history, and experienced 3 to 12 migraines per month, but had 15 or fewer headache days per month during the day baseline period.

Trokendi XR is contraindicated in patients with recent alcohol use within 6 hours prior to and 6 hours after Trokendi XR use. The primary treatment to reverse symptoms is discontinuation of Trokendi XR as rapidly as possible. Elevated intraocular pressure of any etiology, if left untreated, can lead to serious sequelae including permanent vision loss. In clinical trials, most events were reversible after topiramate discontinuation. If problems occur at any time during topiramate treatment, consider discontinuation of the drug. Patients, especially pediatric patients, should be monitored closely for evidence of decreased sweating and increased body temperature, especially in hot weather.

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