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A generalized linear model calculated adjusted total healthcare costs per member controlling for age, sex, geographic region, and clinical characteristics. Higher out-of-pocket costs were associated with higher rates of reversal, and reversals were associated with higher rates of rehospitalization and adjusted total healthcare costs among Medicare members prescribed oral linezolid posthospitalization for SSTI or pneumonia. This implied that oral linezolid and alternative antibiotics or the absence of treatment were similarly cost-effective. However, one limitation of the study by Ball and colleagues was that diagnosis for the initial hospitalization was not confirmed for an infection indicated for linezolid treatment. Members from both commercial and Medicare lines of business were initially identified for the study, but all analyses were conducted separately by line of business because of significant differences in plan reimbursement. All data sources were merged using de-identified member data.

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