Sir Michael has today made clear that the Transport Secretary, Chris Grayling, needs to get a grip on the ongoing issue of train timetables. The Sevenoaks MP pushed for Thameslink to offer alternative transport solutions for passengers when rail services do not run properly, as well as a proper compensation scheme to be in line with the disruption that commuters have suffered. Southeastern services stopping at Eynsford and Shoreham would ease pressure on Thameslink and I have urged them to do that so my constituents are not further inconvenienced. Thameslink have failed to prepare for the new timetable by not training enough drivers in time. Sir Michael will fight to ensure his constituents are not further inconvenienced. My constituents are rightly angry at how these timetables have been implemented and I will continue to press for other rail operators to deploy train drivers who know the London-Kent routes.

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Avodart dutasteride soft gelatin capsules are indicated for the treatment of symptomatic benign prostatic hyperplasia BPH in men with an enlarged prostate to Avodart in combination with the alpha-adrenergic antagonist, tamsulosin, is indicated for the treatment of symptomatic BPH in men with an enlarged prostate. This decrease was predictable over the entire range of PSA values in subjects with symptomatic BPH, although it may vary in individuals. Avodart may also cause decreases in serum PSA in the presence of prostate cancer. Any confirmed increase from the lowest PSA value while on Avodart may signal the presence of prostate cancer and should be evaluated, even if PSA levels are still within the normal range for men not taking a 5 alpha-reductase inhibitor. Noncompliance with Avodart may also affect PSA test results. Coadministration of dutasteride and tamsulosin resulted in similar changes to serum PSA as dutasteride monotherapy. Prior to initiating treatment with Avodart, consideration should be given to other urological conditions that may cause similar symptoms. In addition, BPH and prostate cancer may coexist. Avodart capsules should not be handled by women who are pregnant or may be pregnant.

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Common side effects include sexual problems, breast tenderness, and breast enlargement. Dutasteride is used for treating benign prostatic hyperplasia BPH ; colloquially known as an enlarged prostate. The primary area for concern is for patients who may develop prostate cancer whilst taking dutasteride for benign prostatic hyperplasia, which in turn could delay diagnosis and early treatment of the prostate cancer, thereby potentially increasing the risk of these patients developing high-grade prostate cancer. Sexual dysfunction, such as erectile dysfunction, loss of libido, or reduced semen volume, may occur in 3. There is no specific antidote for overdose of dutasteride. It was approved for the treatment of scalp hair loss in South Korea since and in Japan since

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There has been a lot of interest by both patients and physicians in dutasteride, which is a drug that inhibits both type I and type II 5 alpha reductase enzyme. The function of this enzyme in the brain is still unclear. This was a randomized, placebo-controlled study of men for a 24 week treatment period. The study evaluated various doses of dutasteride versus 5 mg of finasteride versus placebo. At the time of the study the 1 mg finasteride dose Avodart 2.5 mg was not commercially available, but the comparison is valid since the effects on hair growth of 5 mg. When an expert panel evaluated photographs before and after treatment, the 2.

It does this by inhibiting the action of both types Type I and II 5-alpha reductase enzyme. In contrast, finasteride, the FDA approved medication for hair loss, inhibits only the Type II enzyme, the enzyme that is present in highest concentrations in and around the hair follicles. Both dutasteride and finasteride produce a rapid decrease in serum DHT concentration. Dutasteride Avodart inhibits both type I and type II, 5a-reductase. Type I receptors inhibited by dutasteride are present in other organs of the body besides the skin, including the liver and kidneys.

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Finally, a head-to-head study of the 5 alpha reductase blockers and their effect on hair loss! If fact it has been safe recommended therapy since However, it is not the only drug that blocks DHT the hormone that causes male pattern hair loss. Dutasteride aka Avodart also blocks the creation of this hormone, and is more potent. For a long time, however, hair doctors avoided prescribing dutasteride for hair loss since the studies to prove it worked in androgenetic alopecia had never been done.

In males, AGA can begin as early as late adosescence; however, the usual onset is at around the age of 30 years 1. Testosterone is the major circulating androgen in the body, but must be converted to dihydrotestosterone DHT via the enzyme 5 a -reductase in order to be active in the skin 3. Type 1 is distributed throughout the body, and predominates in the skin and scalp 3. At the time this study was cnducted, the 1-mg dosage strength of finasteride that is currently approved for the treatment of AGA was not available 7. Ther primary efficacy parameter was the hair count ina 1-inch diameter circle, with a target area of 0.

Dutasteride is an oral synthetic 4-azasteroid, is a potent, selective, irreversible inhibitor of type avodart 2.5 mg and type 2 -5alpha-reductase 5AR, the enzyme that converts testosterone to dihydrotestosterone DHT intracellularly. Dutasteride is approved by the Korean FDA treatment of hair loss. In one of the studies conducted, dutasteride 0. In another week, double-blind, placebo controlled, dose-ranging study, dutasteride increased hair growth in a dose-dependent manner. Other studies have confirmed efficacy of oral dutasteride compared with placebo in men with androgenetic alopecia as well as in comparison with finasteride. The adverse effect profile of dutasteride is quite similar to finasteride with the difference being in the plasma half-life of the drugs.

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