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Type 2 diabetes can be described as a syndrome characterized by insulin deficiency, insulin resistance and increased hepatic glucose output. Current recommendations of the American Diabetes Association include a trial of diet and exercise as first-line therapy for the treatment of patients with type 2 diabetes. Once the decision is made to initiate therapy with an oral agent, it is prudent to consider patient-specific age, weight, level of glycemic control and agent-specific characteristics relative potencies, duration of action, side-effect profiles, cost to make the most appropriate choice Tables 2 and 3 8. Figure 1 illustrates a reasonable stepwise approach for initiating oral therapy in patients with type 2 diabetes and is consistent with the recommendations put forth by several expert committees and diabetes subspecialists. Sulfonylureas have remained the mainstay of antidiabetic therapy since the early s. Sulfonylureas work by stimulating insulin release from the beta cells of the pancreas and may slightly improve insulin resistance in peripheral target tissues muscle, fat. On average, this class reduces glycosylated hemoglobin A 1c HbA 1c levels by 0. It is of particular concern with agents that are metabolized to an active metabolite with significant renal excretion.

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Micronase comes from the class of sulfonylurea which is used to lower the blood glucose level. This drug contains glyburide in it which is a white, crystalline compound. There are some inactive ingredients also present in it such as colloidal silicon dioxide, dibasic calcium phosphate, magnesium stearate, and sodium alginate. Glyburide present in Micronase is widely used along with a proper diet and exercise regime to control the excess of blood sugar in people with having diabetes. This drug does not interact with the diabetes medicine and thus it can be used along with the diabetes medications. The Micronase should be taken orally by mouth.

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