In general, muscle relaxants should be zanaflex 8mg 2mg temporarily eg, for a few days or intermittently for a few days when needed Ref. Note: For muscle spasticity due to neurologic injury or disease eg, multiple sclerosis, stroke, spinal cord injury, traumatic brain injury, amyotrophic lateral sclerosis ALS Ref. In the treatment of spasticity associated with stroke eg, hemiplegic shoulder pain, some experts initiate therapy with 2 mg every 8 hours as needed Ref. The renal dosing recommendations are based upon the best available evidence and clinical expertise. Altered kidney function: Oral Start at the low end of the dosing range and monitor for side effects with increased doses Ref. If higher doses are necessary, consider increasing the dose instead of increasing dosing frequency Ref.

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