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Not all pain relievers are created equal, and can cause stomach or gastrointestinal GI damage. Other pain relievers known as nonsteroidal anti-inflammatory drugs NSAIDs can cause stomach ulcers and are associated with an increased risk of severe stomach bleeding. The answer is yes, you can! Acetaminophen is a non-aspirin pain reliever that is generally safe and gentle on the stomach, when used as directed. Most OTC Pain Relievers work by blocking the production of naturally occuring chemicals known as prostaglandins which play an important role in pain and inflammation. They do this by inhibiting two main type of enzymes, known as COX-1 and COX-2, which are responsible for prostaglandin production. COX-1 also plays an important role in the Gi tract to help maintain the stomach and intestinal lining, protecting them from harsh stomach acid. As a by-product, these medications can increase the risk for GI problems like ulcers and, in severe cases, stomach bleeding. Gastroesophageal reflux — discharge.

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People who take nonsteroidal anti-inflammatory drugs NSAIDs other than aspirin such as naproxen may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. These problems may develop at any time during treatment, but the risk may be higher for people who take NSAIDs for a long time or at higher doses. Do not take an NSAID such as naproxen if you have recently had a heart attack, unless directed to do so by your doctor. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke, if you smoke, and if you have or have ever had high cholesterol, high blood pressure, or diabetes.

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