Arterial hypertension is associated with platelet activation, increased sCD40L levels and endothelial dysfunction suggesting that inhibition of platelet-derived sCD40L release may improve endothelial function and lower blood pressure BP. Design: Randomized, controlled, investigator-blinded, parallel-group, 2-phase trial in patients with coronary artery disease and essential arterial hypertension and those without hypertension. Outcome Measures: Primary outcome measure is the change in BP from baseline. Secondary outcome measures are changes in biomarkers of platelet and endothelial function and their correlation with BP.

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Plavix is an antiplatelet drug; specific and active inhibitor of platelet aggregation; has a coronary-dilating effect. The use of Plavix is indicated for the prevention of atherothrombotic complications in adult patients with myocardial infarction in adult patients with an acute coronary syndrome. The drug is also indicated to prevent atherothrombotic and thromboembolic complications, including a stroke, atrial fibrillation in patients with atrial fibrillation, who have at least one risk factor for vascular complications and who cannot take indirect anticoagulants and have a low risk of bleeding.

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