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Sulfasalazine is an antiinflammatory agent used extensively in chronic, long term therapy of inflammatory bowel disease. Sulfasalazine is a modified sulfonamide composed of sulfapyridine that is covalently linked to 5-aminosalacyclic acid 5-ASA. Sulfasalazine was approved for clinical use in the United States in and is still commonly used. Current indications are for treatment of active ulcerative colitis and prevention of relapses in disease, both in adults and children. Sulfasalazine is also used for juvenile or adult rheumatoid arthritis. The usual dose in adults is 3 to 4 grams daily initially, with maintenance dosage of 2 grams daily 4 divided doses.
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