Clomipramine, sold under the brand name Anafranil among others, is a tricyclic antidepressant TCA. It has also been used to treat premature ejaculation. Common side effects include dry mouth, constipation, loss of appetite, sleepiness, weight gain, sexual dysfunction, and trouble urinating. Clomipramine was discovered in by the Swiss drug manufacturer Ciba-Geigy. Although lithium is most-associated with the treatment of bipolar disorder where it is known for its general mood-stabilising features and to be especially useful in treating and preventing mania, it may have a certain place in the management of treatment-resistant depression which is often of higher severity than other depressions which have not been addressed with ECT.

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Antidepressants increased the risk compared to placebo of suicidal thinking and behavior suicidality in children, adolescents, and young adults in short-term studies of major depressive disorder MDD and other psychiatric disorders. Clomipramine hydrochloride USP is a white to off-white crystalline powder. It is freely soluble in water, in methanol, and in methylene chloride, and insoluble in ethyl ether and in hexane. The obsessions or compulsions must cause marked distress, be time-consuming, or significantly interfere with social or occupational functioning, in order to meet the DSM -III-R circa diagnosis of OCD. CMI-treated patients experienced a 3. The effectiveness of Anafranil for long-term use i. The treatment regimens described below are based on those used in controlled clinical trials of Anafranil in adults, and 91 children and adolescents with OCD. The goal of this initial titration phase is to minimize side effects by permitting tolerance to side effects to develop or allowing the patient time to adapt if tolerance does not develop.

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These natural substances reduce the anxiety and unpleasant thoughts that cause obsessive-compulsive disorder and depression. By enhancing the actions of norepinephrine and serotonin Anafranil improves the communication between the brain nerves, thus relieving chronic pain syndromes associated with somatic diseases or not. Anafranil is used to treat depression, especially such syndromes as psychomotor retardation and anxiety. It relieves chronic pain syndromes by improving neurotransmission between the brains neurons. Dosage should be individually adjusted according to the patient's condition. Doses should be kept as low as possible and increased cautiously.

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After titration, total daily dose may be given at bedtime. Increased risk of suicidal thinking and behavior in children, adolescents, and young adults; monitor for clinical worsening and unusual changes. Monitor for emergence of serotonin syndrome; discontinue if occurs. History of seizures or other predisposing factors eg, brain damage, alcoholism. Hepatic or renal dysfunction; monitor.

In children and adolescents, there is not sufficient evidence of safety and efficacy of clomipramine in the treatment of depressive states, phobias and cataplexy associated with narcolepsy. The use of clomipramine in children and adolescents years of age in these indications is therefore not recommended see section 4. After a response has been obtained, maintenance therapy should be continued at the optimum dose to avoid relapse. Patients with a history of recurrence require maintenance treatment for a longer duration. As a precaution against possible QTc prolongation and serotonergic toxicity, adherence to the recommended doses of clomipramine is advised and any increase in dose should be made with caution if drugs that prolong QT interval or other serotonergic agents are co-administered see sections 4. Abrupt discontinuation of clomipramine therapy should be avoided because of possible withdrawal symptoms.

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It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you taking this medicine against the benefits it can provide. The symptoms of these disorders vary from person to person. Ask your doctor if you have any questions about why this medicine has been prescribed for you.

The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is buy celexa without rx, effective, or appropriate for any given patient. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. Manufactured by Novartis India Ltd. Obsessive Compulsive Disorder. How long does it take for this medicine to take effect?

A small number of children, teenagers, and young adults up to 24 years of age who took antidepressants 'mood elevators' such as clomipramine during clinical studies became suicidal thinking about harming or killing oneself or planning or trying to do so. Children, anafranil 25mg tablets, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant. Children younger than 18 years of age should not normally take clomipramine, but in some cases, a doctor may decide that clomipramine is the best medication to treat a child's condition. You should know that your mental health may change in unexpected ways when you take clomipramine or other antidepressants even if you are an adult over age

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