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Repaglinide is used as monotherapy as an adjunct to diet and exercise for the management of type 2 diabetes mellitus in patients whose hyperglycemia cannot be controlled by diet and exercise alone. Because of its short duration of action, repaglinide may be particularly suited for control of postprandial hyperglycemia in patients with type 2 diabetes mellitus. However, comparative studies are needed to elucidate the relative efficacy of repaglinide versus other short-acting sulfonylureas e. The American Diabetes Association ADA currently classifies diabetes mellitus as type 1 immune mediated or idiopathic, type 2 predominantly insulin resistance with relative insulin deficiency to predominantly an insulin secretory defect with insulin resistance, gestational diabetes mellitus, or that associated with certain conditions or syndromes e.

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