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Base-case analysis considered costs and outcomes from the US payer perspective. Patients treated with AOM were estimated to have fewer mood episodes and hospitalizations per patient 5. Bipolar disorder BP is a lifelong mood disorder involving periods of mania, hypomania or depression, causing disruptions to mood and potentially severe impairments in functioning. BP-I is estimated to have a lifetime prevalence of 0. BP-I represents a substantial economic burden arising from direct and indirect costs. Treatment outcomes in BP remain unsatisfactory. Currently available pharmacological therapies for acute or maintenance treatment include mood stabilizers e. Oral aripiprazole also has proven efficacy as a maintenance treatment for BP-I. A week, double-blind, placebo-controlled, randomized withdrawal study of AOM as a maintenance monotherapy treatment in patients with BP-I demonstrated that AOM delayed the time to, and reduced the rate of, recurrences of mood episodes relative to placebo and was generally safe and well tolerated NCT;. The model state structure consisted of six states: euthymia while on first-line treatment, euthymia while on subsequent treatment, acute mania, mixed episode, acute depression and death Figure 1.

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