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The results of the trial appear in the British Medical Journal. The Effectiveness of Spironolactone for Women with Acne Vulgaris SAFA trial recruited more than women, aged 18 or older, with acne that had persisted for longer than six months and where oral antibiotics would have normally been the next treatment. Since finishing the trial, Kelly has been able to stay on spironolactone and has now been acne-free for more two years. May 17, Study: Spironolactone May Be an Alternative to Antibiotics for Women With Persistent Acne Women taking spironolactone saw a significant improvement in their acne after 12 and 24 weeks compared to those taking placebo.

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Spironolactone has caused tumors in laboratory animals.

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There did not seem to be a difference in effectiveness between women who had PCOS and those who did not, the researchers noted.

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