Journal of Translational Medicine volume 14, Article number: 83 Cite this article. Synergistic cytotoxicity with high-dose statins and erlotinib has been demonstrated in preclinical models across a number of tumour types. In this phase I study, we evaluated the safety and potential anti-tumour activity of escalating doses of rosuvastatin in combination with the standard clinical dose of erlotinib in heavily pretreated patients with advanced solid tumours. In order to expand the experience and to gain additional safety and pharmacokinetic data, two expansions cohorts using concurrent or alternating weekly dosing regimens at the RPTD were also evaluated. All 24 patients enrolled were evaluable for toxicity, and 22 for response. Plasma erlotinib levels on study were unaffected by the addition of rosuvastatin. Deregulated or elevated activity of HMG-CoA reductase has been demonstrated in a variety of different tumours 17, 18.

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The drug comes as a tablet that you swallow. Crestor is used together with diet or other treatments to lower certain lipids fats in the blood in adults and some children. Crestor is also used to lower the risk of certain cardiovascular heart or blood vessel problems, including the risk of heart attack and stroke. Crestor can also decrease the need for certain blood vessel procedures in the future. Its active ingredient is rosuvastatin. An active ingredient is what makes a drug work. This article describes the dosages of Crestor, as well as its strengths and how to take it. All doses are listed in milligrams mg.

The Ministry of Public Health. International Health Regulations. Epidemiological Surveillance. National Tuberculosis Program. No Tobacco Control Program. Lebanon National Drugs Database.

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Hyperuricemia, acute gouty arthritis; myalgia, muscle spasms, arthralgias; increased aspartate aminotransferase. Potential for significant drug interactions; eg, increased risk of myopathy with statins, enhanced anticoagulant effect of warfarin. Do not hold cholestyramine in mouth for prolonged periods may cause tooth discoloration or enamel decay. Nausea, bloating, cramping, and constipation; elevations in hepatic transaminases and alkaline phosphatase. Not recommended for use in most patients due to poor tolerability and lack of efficacy for clinical endpoints. Prostaglandin-mediated cutaneous flushing, headache, warm sensation, and pruritus; hyperpigmentation particularly in intertriginous regions, acanthosis nigricans, and dry skin; nausea, vomiting, diarrhea; myositis; hyperglycemia, hyperuricemia; hypotension; increased risk of infection.

Rosuvastatin is also taken to lessen the risk of a heart attack or stroke. It works by slowing the production of cholesterol in your body. You should not take rosuvastatin if you are allergic to it, or if you have Do not take rosuvastatin if you are pregnant. It could harm the unborn baby. Use effective birth control to prevent pregnancy while you are taking rosuvastatin.

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These changes include removing the contraindication against using these medicines in all pregnant patients. Because the benefits of statins may include prevention of serious or potentially fatal events in a small group of very high-risk pregnant patients, contraindicating these drugs in all pregnant women is not appropriate. FDA expects removing the contraindication will enable health care professionals and patients to make individual decisions about benefit and risk, especially for those at very high risk of heart attack or stroke. This includes patients with homozygous familial hypercholesterolemia and those who have previously had a heart attack or stroke. Medicines in the statin class include atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin.

Crestor is used in adults and children who are at least 8 years old to lower cholesterol and triglycerides in the blood. Crestor is used in adults to slow the progression of atherosclerosis a build-up of plaque in blood vessels that can block blood flow. Crestor is used to lower the risk of stroke, heart attack, and certain other heart complications in men 50 years and older and women 60 years and older who have coronary heart disease or other risk factors. For the heterozygous type, Crestor can be used in children who are at least 8 years old. For the homozygous type, this medicine can be used in children as young as 7 years old.

Some simple steps can help minimize or avoid muscle problems from Crestor and other cholesterol-lowering drugs. All drugs have side effects. The trick is to weigh the potential for serious side effects against the gain you can get from the medication. Some people are more prone to muscle problems from Crestor and other statins than others. You are in this category if you. If any of these apply to you, it's prudent to start with a low-dose statin and slowly work your way up to what's needed to get your cholesterol to a safe level while having your doctor closely monitor you for problems.

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