All FDA black box warnings are at the end of this fact sheet. Olanzapine is a medication that works in the brain to treat schizophrenia. Olanzapine rebalances dopamine and serotonin to improve thinking, mood, and behavior. Symptoms of schizophrenia include This medication sheet will focus primarily on schizophrenia.

The tablet will dissolve rapidly and be swallowed in the saliva. The tablet may be administered with fluid if needed, but it is not necessary to do so. Immediate-release intramuscular injection Zyprexa IntraMuscular Do not administer intravenously or intra-arterially. Inject deeply into the gluteal muscle to minimize tissue irritation. Use solution within 1 hour; discard any unused portion.

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It may also be used in combination with other medication to treat depression. This medication can help to decrease hallucinations and help you to think more clearly and positively about yourself, feel less agitated, and take a more active part in everyday life. Intramuscular IM injection, short-acting. Used as monotherapy or in combination with lithium or valproate. Renal impairment: Dose adjustment not necessary. Hepatic impairment: Dose adjustment may be necessary; use caution. This document does not contain all possible side effects and others may occur. What Other Drugs Interact with Olanzapine? Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

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When prescribing, dispensing or administering, check that this is the correct preparation—this preparation is used for maintenance treatment and should not be used for the rapid control of an acute episode. An ECG may be required, particularly if physical examination identifies cardiovascular risk factors, personal history of cardiovascular disease, or if the patient is being admitted as an inpatient. See also Prescribing in the elderly. Bone-marrow depression; hypereosinophilic disorders; low leucocyte count; low neutrophil count; myeloproliferative disease; paralytic ileus; when transferring from oral to depot therapy, the dose by mouth should be reduced gradually. Agranulocytosis; confusion; embolism and thrombosis; neuroleptic malignant syndrome discontinue—potentially fatal. Phenothiazines cause less depression of consciousness and respiration than other sedatives.

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Olanzapine long-acting injection LAI is a salt-based depot antipsychotic combining olanzapine and pamoic acid. The authors conducted a series of parallel investigations into the possible reasons PDSS events occur. No anomalies were found with the product batches or the remaining suspension in the used vials. Solubility and dissolution rate of olanzapine pamoate were also found to be substantially greater in plasma than in other media such as those approximating the environment in muscle tissue. Manufacturing irregularities, improper drug reconstitution, and inappropriate dosing were ruled out as possible causes of PDSS.

Pharmaco, the supplier, has advised Pharmac that there is a global supply issue affecting the depot injection olanzapine Zyprexa Relprevv. The next shipment of mg strengths of depot injection olanzapine is expected on the 13 October. Pharmaco are hoping that the mg will be on the same shipment and are waiting for confirmation. However, wholesalers may continue to struggle to fill current backorders for pharmacies. We are still looking at solutions to the supply constraints in November. Pharmac is also investigating additional supplies of the mg.

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Olanzapine sold under the trade name Zyprexa among others is an atypical antipsychotic primarily used to treat schizophrenia and bipolar disorder. Common side effects include weight gain, movement disorders, dizziness, feeling tired, constipation, and dry mouth. Olanzapine was patented in and approved for medical use in the United States in In United Kingdom and Australia it is approved for schizophrenia, moderate to severe manic episodes, alone, or in combination with lithium or valproate and the short-term treatment of acute manic episodes associated with Bipolar I Disorder. The first-line psychiatric treatment for schizophrenia is antipsychotic medication. Olanzapine is recommended by the National Institute for Health and Care Excellence as a first-line therapy for the treatment of acute mania in bipolar disorder.

For coverage of additional quantities, a member's treating physician must request prior authorization through the Pharmacy Management Precertification Unit. See criteria under section III below. Greenwood Village, Colo: Thomson Micromedex. Drug Facts and Comparisons on-line. Practice parameter on the use of psychotropic medication in children and adolescents. A week, randomized, double-blind study of olanzapine versus aripiprazole in the treatment of schizophrenia.

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