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Cetirizine hydrochloride is an orally-active and selective histamine H 1 -receptor antagonist. Therefore, its principal effects are mediated via selective inhibition of peripheral H 1 receptors. The antihistaminic activity of cetirizine has been documented in a variety of animal and human models. In clinical studies, however, dry mouth has been seen more commonly with cetirizine than with placebo. It has anti-inflammatory properties that may play a role in asthma management.

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