A drug currently used to treat several psychiatric conditions can help prevent nausea and vomiting in patients receiving chemotherapy, according to results from a large NCI-funded phase III clinical trial. Patients in the trial were being treated with chemotherapy agents that often cause substantial nausea and vomiting. The antiemetic drugs—all of which act on components of the central nervous system—include dexamethasone a type of steroid and agents from two classes of therapies known as 5-HT 3 receptor antagonists and NK-1 receptor antagonists. Olanzapine, which is approved by the Food and Drug Administration for the treatment of schizophrenia and bipolar disorder, targets receptors in the brain that have been linked to nausea and vomiting. More than patients were enrolled in the randomized trial.

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Sections without translation will be in English. To evaluate the efficacy and safety of different doses of olanzapine for people with schizophrenia. Schizophrenia is a complex and severe mental illness that has a significant impact on individuals and their families Owen It usually starts in early adulthood and in rare cases, during childhood or old age. Slightly more men are diagnosed with schizophrenia than women and women tend to have a later onset Abel Schizophrenia affects how a person thinks, feels, and behaves. People with schizophrenia often experience stigma and discrimination and violation of their human rights WHO, and are more likely to be single and unemployed Messias Studies have also found that adults with schizophrenia have more cardiovascular and chronic obstructive pulmonary diseases in addition to a higher mortality rate compared to the general population. On average, people with schizophrenia die

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Olanzapine is a psychiatric drug that belongs to the atypical antipsychotics class of drugs. It is sold under the brand name Zyprexa. It risperdal 0.75 mg ingested orally or taken through an intramuscular injection. It is used for new disease onset or one that needs treatment over a long time for the treatment of schizophrenia. It was first patented in as a general psychiatric medication. It is often used in conjunction with other medication therapies.

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We examined the efficacy of olanzapine for the prevention of nausea and vomiting in patients receiving highly emetogenic chemotherapy. The doses of the three concomitant drugs administered before and after chemotherapy were similar in the two groups. The two groups received either 10 mg of olanzapine orally or matching placebo daily on days 1 through 4. Nausea prevention was the primary end point; a complete response no emesis and no use of rescue medication was a secondary end point. In the analysis, we included patients who could be evaluated assigned to olanzapine, and to placebo. Olanzapine, as compared with placebo, significantly improved nausea prevention, as well as the complete-response rate, among previously untreated patients who were receiving highly emetogenic chemotherapy.

It may also be used in combination with other medication to treat depression. This medication can help to decrease hallucinations and help you to think more clearly and positively about yourself, feel less agitated, and take a more active part in everyday life. Talk to the doctor about the risks and benefits of treatment especially when used in teenagers. Intramuscular IM injection, short-acting. Used as monotherapy or in combination with lithium or valproate. Renal impairment: Dose adjustment not necessary.

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The tablet will dissolve rapidly and be swallowed in the saliva. The tablet may be administered with fluid if needed, but it is not necessary to do so. Immediate-release intramuscular injection Zyprexa IntraMuscular Do not administer intravenously or intra-arterially. Inject deeply into the gluteal muscle to minimize tissue irritation. Use solution within 1 hour; discard any unused portion.

Schizophrenia, a disease of the brain, is one of the most disabling and emotionally devastating illnesses known to man. But because it has been misunderstood for so long, it has received relatively little attention and its victims have been undeservingly stigmatized. Schizophrenia is not a split personality, a rare and very different disorder. Like cancer and diabetes, schizophrenia has a biological basis; it is not caused by bad parenting or personal weakness. Schizophrenia is, in fact, a relatively common disease, with an estimated one percent to one and a half percent of the U. While there is no known cure for schizophrenia, it is a very treatable disease.

It's also used to treat depression when used with other medications. By taking this drug you may be able to decrease hallucinations, reduce feelings of agitation, and think more clearly and positively. This medication is also used for preventing chemotherapy-induced nausea and vomiting. Unless directed by your doctor, never use Zyprexa for off-label use. In, the FDA approved Zyprexa Relprevv extended-release injectable suspension to treat adults with schizophrenia. The intramuscular injection, which comes in milligram mg, mg, and mg, can sustain the delivery of the drug for up to four weeks.

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