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Distributor: Zuellig Pharma. COX-1 is responsible for prostaglandin-mediated normal cheap zantac functions such as gastric cytoprotection and platelet aggregation. Selective inhibition of COX-2 by etoricoxib decreases these clinical signs and symptoms with decreased GI toxicity and without effects on platelet function. The influence on gastroprotective COX-1 activity was also assessed in a clinical study where prostaglandin synthesis was measured in gastric biopsy samples from subjects administered either ARCOXIA mg daily, naproxen mg twice daily, or placebo.

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