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Because monotherapy is effective in achieving this target goal in only about 50 percent of patients, treatment with two or more agents from different pharmacologic classes is often necessary to achieve adequate blood pressure control. The rationale for using fixed-dose combination therapy is to obtain increased blood pressure control by employing two antihypertensive agents with different modes of action and to enhance compliance by using a single tablet that is taken once or twice daily. Diuretics are effective antihypertensive drugs. Treatment with a diuretic such as hydrochlorothiazide results in a dose-dependent blood pressure reduction that levels off with higher dosages Table 2. Unfortunately, the degree of improvement in cardiovascular mortality is less than would have been expected based on epidemiologic data. One postulated but not yet proven explanation is that the higher diuretic dosages used in the large trials cause relative hypokalemia, as well as increased serum lipid levels, insulin resistance and uric acid levels. These adverse metabolic effects counteract the positive cardiovascular benefits of blood pressure reduction. Such effects do not occur when diuretics are administered in a low dosage, such as 6.

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Medindia» Drugs» Drug Price» Amlodipine. Amlodipine Norvasc generic is a calcium channel blocker, prescribed for high blood pressure and chest pain. It widens blood vessels and improves blood flow by not making the heart pump harder. It widens blood vessels and improves blood flow. More Info about Amlodipine. Drug Name: Amlodipine Amlodipine Norvasc generic is a calcium channel blocker, prescribed for high blood pressure and chest pain.

Please note brand received may vary. Disclaimer: The prices cheap amlodipine should only be used as a reference of our prices for this medicine. Amlodipine is a calcium channel blocker that is primarily used in the treatment of high blood pressure. It is also widely used to treat chronic stable angina and to prevent future heart disease, heart attacks and strokes. Amlodipine helps to lower blood pressure by widening the blood vessels.

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