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Common side effects of promethazine include confusion and sleepiness; 4 consumption of alcohol or other sedatives can make these symptoms worse. This also means high doses act as a deliriant. Some documented side effects include Because of potential for more severe side effects, this drug is on the list to avoid in the elderly. Promethazine is listed as one of the drugs of highest anticholinergic activity in a study of anticholinergenic burden, including long-term cognitive impairment.

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