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Context: Although olanzapine has been widely adopted as a treatment of choice for schizophrenia, its long-term effectiveness and costs have not been evaluated in a controlled trial in comparison with a standard antipsychotic drug. Objective: To evaluate the effectiveness and cost impact of olanzapine compared with haloperidol in the treatment of zyprexa 20 mg cost. Participants: Three hundred nine patients with a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition diagnosis of schizophrenia or schizoaffective disorder, serious symptoms, and serious dysfunction for the previous 2 years. Main outcome measures: Standardized measures of symptoms, quality of life, neurocognitive status, and adverse effects of medication. Results: There were no significant differences between groups in study retention; positive, negative, or total symptoms of schizophrenia; quality of life; or extrapyramidal symptoms. Small but significant advantages were also observed on measures of memory and motor function.

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