Therapy should be initiated with low doses, gradually increased. Final dose may be a compromise between mobility and side- effects. Rotigotine is recommended for use only within its licensed indications i. Rotigotine requires dose titration. Other secondary cases should be referred to a specialist for diagnosis e. Try to avoid drugs that can exacerbate symptoms CNS stimulants, diuretics, tricyclic antidepressants, calcium antagonists, phenytoin.

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It is required before any medicine is allowed on the market in Europe. It is designed to assist doctors and pharmacists in prescribing and supplying the product. Reasons for updating New SmPC for new product. Reasons for updating New PIL for new product. Reasons for updating Change to section sinemet 250 25 mg.

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Your medication may look different. If you have questions, ask your pharmacist. This combination medication is used to treat symptoms of Parkinson's disease or Parkinson-like symptoms such as shakiness, stiffness, difficulty moving. Levodopa changes into dopamine in the brain, helping to control movement. Carbidopa can also reduce some of levodopa's side effects such as nausea and vomiting. If you have any questions, ask your doctor or sinemet 250 25 mg.

Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier Label. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prevent metabolism until after it has crossed the blood-brain barrier Label, 1. Once past the blood-brain barrier, levodopa is metabolized to dopamine and supplements the low endogenous levels of dopamine to treat symptoms of Parkinson's Label. A governmentally-recognized ID which uniquely identifies the product within its regulatory market. Levodopa is able to cross the blood-brain barrier while dopamine is not Label, 8.

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Patients receiving less than this amount of carbidopa are more likely to experience nausea and vomiting. Standard antiparkinsonian drugs, other than levodopa alone, may be continued while 'Sinemet' is being administered, although their dosage may have to be adjusted. Because both therapeutic and adverse effects are seen more rapidly with 'Sinemet' than with levodopa, patients should be carefully monitored during the dosage adjustment period. Involuntary movements, particularly blepharospasm, are a useful early sign of excess dosage in some patients. This dosage schedule provides 75 mg of carbidopa per day. Titration upward may be required in some patients to achieve optimum dosage of carbidopa.

Take this medicine exactly as directed, and every time that you are supposed to take it. Do not stop taking your medicine unless ordered by your doctor. It is also important to not start taking other medicines for your Parkinson's disease without first talking with your doctor. You should tell your doctor if you have problems with this that affect your every day life. Your doctor may want to adjust your dose. Since protein may interfere with the body's response to carbidopa and levodopa, high protein diets should be avoided.

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