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Ernst, clinical professor at the University of Iowa College of Pharmacy and researcher on blood pressure variability, told Healthline. Therefore, they are not usually used as a monotherapy, but are usually reserved for adding to other antihypertensives when the existing regimen fails to achieve the goal blood pressure. Prior research from revealed a link between large variations in blood pressure and increased mortality risk. Then, during the American College of Cardiology Scientific Session, researchers warned that alpha-blockers and alpha-2 agonists were more associated with blood pressure variability than other commonly used medications. According to researchers, that variation in blood pressure was linked to an increased risk of death. The researchers recorded both blood pressure variation as well as the blood pressure medication used by each participant. The study authors advocated for physicians to prescribe other blood pressure medications to decrease mortality risk for their patients.

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Irbesartan, sold under the brand cheap irbesartan Avapro among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease. Common side effects include dizziness, diarrhea, feeling tired, muscle pain, and heartburn. Irbesartan was patented in, and approved for medical use in The medicine has an extended diphenyl group with a tetrazole at the 2-prime position. At the 4'prime position, the molecule has a diazaspironone, which is on a methyl.

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