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Ibuprofen: Which is Right For You? In this article, we will compare two medications — diclofenac and ibuprofen. Both are NSAIDs and are frequently used by patients with arthritis and other illnesses subjected to chronic pain with no evidence of renal impairment. A nonsteroidal anti-inflammatory drug can either be selective for COX-1 or COX-2 enzyme, thereby blocking a portion of prostaglandin synthesis or nonselective by blocking both COX-1 and COX-2, thereby diminishing prostaglandin synthesis to an even greater degree.

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Meet your Best of the Best Pharmacy Award winners! If you experience pain from arthritis on a regular basis, you may be recommended a nonsteroidal anti-inflammatory drug NSAID like diclofenac or ibuprofen. These drugs work by decreasing the production of prostaglandins, or chemicals responsible for inflammation.

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