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The effects of nicotine on the extracellular dopamine release were potentiated by galantamine, but antagonized by mecamylamine, a nAChR antagonist. These improving effects of galantamine were blocked by the treatment with mecamylamine, SCH, a dopamine-D1 receptor antagonist, and sulpiride, a dopamine-D2 receptor antagonist, but not by scopolamine, a reminyl 2mg of acetylcholine receptor antagonist. This study provides the first in vivo evidence that galantamine augments dopaminergic neurotransmission within the hippocampus through the allosteric potentiation of nAChRs. Alzheimer's disease is a progressive and neurodegenerative disorder that is associated with a global impairment of higher mental function, with confusion, loss of memory, and impairment of cognitive function Palmer, In contrast to pure agonist nicotine, the stimulation of the nAChRs by galantamine is synchronized with physiological presynaptic cholinergic activity, thereby avoiding overstimulation and desensitization, and probably leading to an optimal activation of the downstream intracellular pathways Geerts, In the hippocampus, a critical area involved in attention and memory, the significance of nicotinic—dopaminergic interactions for cognitive function has been well documented Hefco et al, ; Levin and Simon,
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