Although intravenous dexamethasone prolongs the analgesic duration of interscalene brachial plexus block, it is uncertain whether this effect can be observed using lower doses of dexamethasone. This study evaluated the impact of intravenous dexamethasone 4 mg and 10 mg on the analgesic duration of single-shot interscalene block after arthroscopic shoulder surgery. We hypothesized that both doses would prolong the analgesic duration compared with placebo. This was a prospective double-blind randomized placebo-controlled study in patients undergoing elective arthroscopic shoulder surgery under regional anesthesia with a single-shot interscalene block 0. Patients received dexamethasone 4 mg D4, dexamethasone 10 mg D10, or a placebo normal saline intravenously at the time of block completion.

The oral solution contains citric acid, disodium edetate, flavoring, glycerin, methylparaben, propylene glycol, propylparaben, sorbitol and water. Primary or secondary adrenocortical insufficiency hydrocortisone or cortisone is the drug of choice; may be used in conjunction with synthetic miner-alocorticoid analogs where applicable;in infancy mineralocorticoid supplementation is of particular importance, congenital adrenal hyperplasia, hypercal-cemia associated with cancer, and nonsuppurative thyroiditis. Acquired autoimmune hemolytic anemia, congenital erythroid hypoplastic anemia Diamond-Blackfan anemia, idiopathic thrombocytopenic purpura in adults, pure red cell aplasia, and selected cases of secondary thrombocytopenia. Diagnostic testing of adrenocortical hyperfunction, trichinosis with neurologic or myocardial involvement, tuberculous meningitis with subarachnoid block or impending block when used with appropriate antituberculous chemotherapy. Acute exacerbations of multiple sclerosis, cerebral edema associated with primary or metastatic brain tumor, craniotomy, or head injury.

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Inactive ingredients are calcium phosphate, lactose, magnesium stearate, and starch. The molecular weight for dexamethasone is Primary or secondary adrenocortical insufficiency hydrocortisone or cortisone is the drug of choice; may be used in conjunction with synthetic mineralocorticoid analogs where applicable; in infancy mineralocorticoid supplementation is of particular importance, congenital adrenal hyperplasia, hypercalcemia associated with cancer, and nonsuppurative thyroiditis. Decreased carbohydrate and glucose tolerance, development of cushingoid state, hyperglycemia, glycosuria, hirsutism, hypertrichosis, increased requirements for insulin or oral hypoglycemic agents in diabetes, manifestations of latent diabetes mellitus, menstrual irregularities, secondary adrenocortical and pituitary unresponsiveness particularly in times of stress, as in trauma, surgery, or illness, suppression of growth in pediatric patients. Congestive heart failure in susceptible patients, fluid retention, hypokalemic alkalosis, potassium loss, sodium retention, tumor lysis syndrome. Abdominal distention, elevation in serum liver enzyme levels usually reversible upon discontinuation, hepatomegaly, increased appetite, nausea, pancreatitis, peptic ulcer with possible perforation and hemorrhage, perforation of the small and large intestine particularly in patients with inflammatory bowel disease, ulcerative esophagitis.

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Indication-specific dosing Prevention, moderate- to high-risk situations alternative agent: Note: Use in addition to gradual ascent and start the day of ascent. Oral: 2 mg every 6 hours or 4 mg every 12 hours; may be discontinued after staying at the same elevation for 2 to 4 days or if descent is initiated. Acute mountain sickness moderate to severe: Note: Dexamethasone does not facilitate acclimatization; further ascent should decadron 4 mg iv delayed until patient is asymptomatic off medication Ref. Oral, IM, IV: 4 mg every 6 hours, continue until 24 hours after symptoms resolve or descent completed not longer than 7 days total Ref.

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Dexamethasone has very high glucocorticoid activity and insignificant mineralocorticoid activity. Dexamethasone is used for the treatment of suspected bacterial meningitis, A but is not licensed for this indication. Dexamethasone is used to reduce peri- and neonatal morbidity and mortality in women with established preterm labour, planned preterm birth, or preterm prelabour rupture of membranes, A but is not licensed for this indication. See Corticosteroids, general use. The card includes a management summary for the emergency treatment of adrenal crisis and sick day dosing, and can be issued by any healthcare professional managing such patients.

Administer with food to minimize GI upset. If given once daily, give in the morning to coincide with the body's normal cortisol secretion. Measure the appropriate dose, using decadron 4 mg iv the calibrated dropper provided with product. Mix the dose with liquid or semi-solid food such as water, juice, soda, applesauce, or pudding and stir the preparation for a few seconds. Use diluted solutions within 24 hours, as infusion solutions generally do not contain preservatives.

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Protect from light and freezing. Opened - Expires 7 days from opening. A controlled trial of dexamethasone in preterm infants at high risk for bronchopulmonary dysplasia. Effects of early dexamethasone therapy on pulmonary mechanics and chronic lung disease in very low birthweight infants: A randomised controlled trial. Collaborative Dexamethasone Trial Group: Dexamethasone therapy in neonatal chronic lung disease: An international placebo-controlled trial.

Use larger doses eg up to mg initially in patients with profound or rapidly progressive neurologic injury, and lower doses in patients with mild or equivocal signs. If a satisfactory clinical response does not occur after a reasonable period of time, discontinue Dexamethasone Sodium Phosphate Injection and transfer the patient to other therapy. Patients should be observed closely for signs that might require dosage adjustment, including changes in clinical status resulting from remissions or exacerbations of the disease, individual drug responsiveness and the effect of stress e. Some of the usual single doses are Dexamethasone Sodium Phosphate Injection is particularly recommended for use in conjunction with one of the less soluble, longer-acting steroids for intra-articular and soft tissue injection. Do not use if solution is hazy or has a precipitate.

It is used in the treatment of various diseases and conditions such as inflammatory and autoimmune conditions. It provides relief from swelling, redness, and pain, by preventing the release of substances that cause inflammation. Decadron Injection is generally given by a healthcare professional and should not be self-administered. You need to use it regularly to get the decadron 4 mg iv benefit of the medicine. Complete the full course to get maximum benefits from the medicine.

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